Combination Antifungal Therapy for Cryptococcal Meningitis
نویسندگان
چکیده
Jeremy N. Day, M.D., Ph.D., Tran T.H. Chau, M.D., Ph.D., Marcel Wolbers, Ph.D., Pham P. Mai, M.D., Nguyen T. Dung, M.D., Nguyen H. Mai, M.D., Ph.D., Nguyen H. Phu, M.D., Ph.D., Ho D. Nghia, M.D., Ph.D., Nguyen D. Phong, M.D., Ph.D., Cao Q. Thai, M.D., Le H. Thai, M.D., Ly V. Chuong, M.D., Dinh X. Sinh, M.D., Van A. Duong, B.Sc., Thu N. Hoang, M.Sc., Pham T. Diep, B.Sc., James I. Campbell, M.I.B.M.S., Tran P.M. Sieu, M.D., Stephen G. Baker, Ph.D., Nguyen V.V. Chau, M.D., Ph.D., Tran T. Hien, M.D., Ph.D., David G. Lalloo, M.D., and Jeremy J. Farrar, M.D., D.Phil.
منابع مشابه
Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection.
OBJECTIVE The role of innate immunity in the pathogenesis of cryptococcal meningitis is unclear. We hypothesized that natural killer (NK) cell and monocyte responses show central nervous system (CNS) compartment-specific profiles, and are altered by antifungal therapy and combination antiretroviral therapy (cART) during cryptococcal meningitis/HIV coinfection. DESIGN Substudy of a prospective...
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We herein report the case of a 72-year-old-man with pulmonary cryptococcoma along with cryptococcal meningitis who underwent surgery for pulmonary lesions while receiving chemotherapy. We noted two major clinical issues. First, the presence of pulmonary cryptococcoma had a detrimental influence on the cryptococcal meningitis. Second, resolution of the pulmonary cryptococcoma through antifungal ...
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BACKGROUND This study aimed to investigate the correlation of minimum inhibiting concentrations (MICs), obtained by broth micro-dilution, and clinical response in patients with cryptococcal meningitis. METHODS Using retrospective analyses covering the period 2001-2010, factors affecting clinical therapeutic cure in patients with cryptococcal meningitis 10 weeks after the start of anti-fungal ...
متن کاملStrategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America.
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies t...
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Cryptococcal meningitis is the leading cause of adult meningitis in sub-Saharan Africa, and contributes up to 20% of AIDS-related mortality in low-income and middle-income countries every year. Antifungal treatment for cryptococcal meningitis relies on three old, off-patent antifungal drugs: amphotericin B deoxycholate, flucytosine, and fluconazole. Widely accepted treatment guidelines recommen...
متن کاملIntegrated therapy for HIV and cryptococcosis
Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common form of cryptococcosis. Laboratory diagnosis of cryptococcosis includes direct microscopic examination, isolation of Cryptococcus from a clinical specimen, and detection of cryptococcal a...
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